Severe acute respiratory syndrome coronavirus (SARS-COV-2) infection has led to a global pandemic and a public health crisis, resulting in over 4,806,841 deaths at the time of publication ( 1). In light of expected third dose, large-scale and well-designed studies are needed to better define possible adverse reactions of the COVID-19 vaccine. However, due to the small sample size, a definite cause–effect relationship between vaccination and vertigo cannot be inferred. Due to the prevalence of nystagmus of non-peripheral origin, a central nervous system involvement could not be excluded. Bedside examination showed absent nystagmus in 7 patients (21.2%), 9 patients (27.3%) had horizontal or rotatory nystagmus, 17 patients (51.5%) had a vertical or oblique nystagmus, negative HST, or “central HINTS.”ĭiscussion and Conclusions: The 9 patients had an evoked nystagmus pathognomonic for benign paroxysmal positional vertigo in the remaining 17 cases, peripheral vestibular dysfunction could be excluded and central disorder may be suggested. Of the associated ear, nose, and throat (ENT) symptoms, the most expressed was tinnitus (18.2%). Results: Symptoms included 16 patients (48.5%) with objective vertigo, 14 patients (42.4%) with subjective vertigo, and 3 patients (9.1%) with dizziness. Head shaking test-induced nystagmus, hyperventilation-induced nystagmus, and parossistic positional nystagmus were studied to search for vestibular impairment. All patients underwent otoneurological evaluation, such as head impulse test, nystagmus evaluation, test of skew (HINTS) examination. A detailed medical history was taken on comorbidities, types of vaccines received, and symptoms associated. Methods: In the period from May to July 2021, we evaluated 33 patients (mean age 54.3 ± 14.1) with “acute vertigo” post COVID-19 vaccination. Objective: The aim of this study was to present some cases of acute vertigo potentially related to the coronavirus disease 2019 (COVID-19) vaccine and review the available literature about cochleovestibular dysfunction after the COVID-19 vaccination. 3Otolaryngology Unit, Di Venere Hospital, Bari, Italy.2Centre of Phoniatry and Rehabilitation of Communication Disorders - Azienda Sanitaria Locale Lecce, Lecce, Italy.Policlinico “G.Rodolico-San Marco”, University of Catania, Catania, Italy 1Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Paola Di Mauro 1 *, Ignazio La Mantia 1, Salvatore Cocuzza 1, Pasqua Irene Sciancalepore 2, Deborak Rasà 1, Antonino Maniaci 1, Salvatore Ferlito 1, Isabella Tundo 1 and Roberta Anzivino 3
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